Antiparasitic agents produced by microorganisms
نویسندگان
چکیده
منابع مشابه
Arylmethylamino steroids as antiparasitic agents
In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC50 1-5 nM) as well as against gametocytes. In P. berghei-infected mice, oral administration of 1...
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Coevolving interactions between a plant population and its microbiota can potentially yield a rhizosphere enriched in metagenomes containing the blueprints for a vast array of natural products. We describe a method of isolating those metabolites through activity-based screening of soil metagenomic libraries. The method allows for the isolation of small molecules produced in vector– host express...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 2004
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.80.245